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BÜHLMANN GanglioCombi® MAG ELISA
The IVDR-compliant BÜHLMANN GanglioCombi® version includes Ganglioside T1a (GT1a), replacing Ganglioside M2 (Profile: «MAG», GM1, GT1a, GD1a, GD1b, GQ1b). BÜHLMANN GanglioCombi® MAG ELISA is the only commercially available multiparametric IVD ELISA test to investigate anti-ganglioside -and anti-MAG (myelin-associated glycoproteins) antibodies in the same approach. Three enzyme labels (IgG/IgM mix, IgG and IgM) allow for cost- and time effective algorithms including testing in 2 steps: (1st) initial screening for antibodies with the IgM/IgG mix followed by (2nd) re-testing of positive samples with IgG- and IgM-enzyme label to identify the underlying pathology.
BÜHLMANN GanglioCombi® MAG ELISA
The IVDR-compliant BÜHLMANN GanglioCombi® version includes Ganglioside T1a (GT1a), replacing Ganglioside M2 (Profile: «MAG», GM1, GT1a, GD1a, GD1b, GQ1b). BÜHLMANN GanglioCombi® MAG ELISA is the only commercially available multiparametric IVD ELISA test to investigate anti-ganglioside -and anti-MAG (myelin-associated glycoproteins) antibodies in the same approach. Three enzyme labels (IgG/IgM mix, IgG and IgM) allow for cost- and time effective algorithms including testing in 2 steps: (1st) initial screening for antibodies with the IgM/IgG mix followed by (2nd) re-testing of positive samples with IgG- and IgM-enzyme label to identify the underlying pathology.
Advantages of BÜHLMANN GanglioCombi® MAG ELISA
The IVDR-compliant BÜHLMANN GanglioCombi® version includes Ganglioside T1a (GT1a), replacing Ganglioside M2 (Profile: «MAG», GM1, GT1a, GD1a, GD1b, GQ1b).
The BÜHLMANN GanglioCombi® MAG ELISA is the ideal and efficient tool to support investigations of autoimmune related peripheral neuropathies. It combines, as unique multiparametric IVD ELISA, MAG and ganglioside antigens on the same profile and thus enables a targeted screening for the most prominent immune-mediated neuropathies. The kit features all enzyme label-conjugates and allows for an economic, efficient and complete work-up in two steps.
Test values may be related and interpreted as 1 of 3 titre categories: negative, positive or equivocal (grey zone), which matches up with the basic concept in autoimmunology where values are rarely black or white. MAG (IgM) positive results point to putative MAG neuropathy or MGUS (monoclonal gammopathy of unknown significance) and may be confirmed with the gold standard anti-MAG Antibodies ELISA.
BÜHLMANN GanglioCombi® MAG ELISA Product Information
| Method | ELISA |
| Analytes | anti-MAG* and –Ganglioside antibodies (GM1, GT1a, GD1a, GD1b, GQ1b) |
| Time to Result | 4.5 h (approx.) |
| Sample type and -volume | serum; 100 uL (1:50) |
| Enzyme-labels | IgG/IgM Mix, IgM and IgG |
| Results | % Ratio of Calibrator |
| Cut-off | 50% |
| Order Code | EK-GCM |
| CE (IVDR compliant) |
* Chemically synthesized HNK-1 epitope of the MAG glycoprotein
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