The anti-MAG Antibodies ELISA has outstanding sensitivity and specificity. In a study with 68 patients, the anti-MAG Antibodies ELISA showed considerably higher sensitivity compared to Western Blot (Kuijf M. et al., 2009).

High titers of IgM anti-MAG antibodies are clearly associated with sensory motor demyelinating peripheral neuropathy. Detection of MAG IgM antibodies by ELISA based on human MAG antigen is also significantly more sensitive and specific than Western Blot or IFA assays using primate antigen (Jaskowsky T. et al., 2008; Kuijf M. et al., 2009). Thus, in contrast to Western Blotting even low anti-MAG antibody titers can be measured that still indicate different neuropathy. With this very high sensitivity of the BÜHLMANN ELISA, the risk missing MAG antibody associated pathology in a suspected neuropathy, can essentially be ruled out.

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