The anti-SGPG Autoantibodies ELISA by BÜHLMANN is a semi-quantitative assay for determining IgM antibodies against SGPG.

Anti-SGPG antibodies have a wider spectrum than anti-MAG antibodies: some patients which are anti-SGPG positive are negative for anti-MAG antibodies. Therefore, combined testing enhances sensitivity.

The presence of anti-MAG/anti-SGPG antibodies is suggestive of a demyelinating neuropathy, whereas the presence of anti-SGPG antibodies alone seems to be more present in axonal non-demyelinating neuropathies, often of predominantly motor-type.

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