VASOPRESSIN

Anti-diuretic hormone (ADH), or [Arg8]-Vasopressin (AVP), is a peptide hormone produced by the hypothalamus and stored in the posterior part of pituitary gland. ADH acts on kidneys, concentrating urine by promoting the re-absorption of water from the cortical collecting duct.
Decreased ADH release leads to diabetes insipidus, a condition featuring hypernatremia (increased blood sodium content), polyuria (excess urine production) and thirst.

THE FIRST COMMERCIALLY AVAILABLE VASOPRESSIN RIA

Raised ADH levels (Syndrome of Inappropriate Antidiuretic Hormone or SIADH), and the resulting hyponatremia, occurs in diseases of the brain and lung. In the perioperative period, the effects of surgical stress and some commonly used medications (e.g. opiates, syntocinon, anti-emetics) lead to a similar state of excess ADH secretion. This may cause mild hyponatremia for several days.

Role in disease
• Decreased ADH levels lead to diabetes insipidus, a condition featuring hypernatremia (increased blood sodium content), polyuria (excess urine production) and thirst.
• Raised ADH (syndrome of inappropriate antidiuretic hormone, SIADH) and resultant hyponatremia occurs in brain diseases and conditions of the lungs.

 

ADVANTAGES OF THE BUHLMANN VASOPRESSIN RIA

Sensitivity 1.25 pg/ml
Specificity <0.001% cross-reactivity with Oxytocin
Reproducibility pre-measured standards and two controls

 

Product Information

Vasopressin Vasopressin Direct
Method 125I-RIA 125I-RIA
Time to Results 48 h 48 h
Sample Type 1 ml EDTA plasma & urine 0.8 ml EDTA plasma
Standard Range 0.63-80  pg/ml 1.25-80  pg/ml
Sensitivity 0.4 pg/ml 0.75 pg/ml
Order Code RK- AR1 100 tests RK- VPD 100 tests
CE CE

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