Intoxication with Amanitin has been reported to be lethal in up to 25% of all cases and the mortality rate in children under 10 years of age is above 50%. Therefore, this intoxication should be ruled out in all patients presenting gastrointestinal symptoms after a mushroom ingestion. Amanitin analysis in urine is a valuable diagnostic tool and does significantly contribute to the management of mushroom poisoning.
Anti-diuretic hormone (ADH, also known as AVP) is a peptide hormone and acts as effector hormone of the hypothalamus for the regulation of the water balance. ADH acts on kidneys, concentrating urine by promoting the re-absorption of water from the cortical collecting duct. Decreased ADH release leads to diabetes insipidus, a condition featuring hypernatremia (increased blood sodium content), polyuria (excess urine production) and thirst.
Angiotensin II has a key position in the Renin-Angiotensin-Aldosterone-System (RAAS), which maintains blood pressure and regulates the bodies water balance. The Angiotensin II RIA was one of the first commercially available Angiotensin II RIA Kits available on the market. It is currently used in both clinical routine labs in addition to a number of research projects investigating hypertensive and normotensive models in rat and mouse.