The principal metabolite of Melatonin is 6-Sulfatoxymelatonin. The particular advantage of measuring 6-Sulfatoxymelatonin is the ability to assess pineal function by urine sampling, since urine contains only traces (approx. 1%) of non-metabolized Melatonin. The measurement of 6-Sulfatoxymelatonin in urine provides a non-invasive, integrated parameter by which circadian rhythms can be assessed over a period of time.
Melatonin is initially metabolized in the liver to 6-Hydroxymelatonin (aMT6S, M6S), then conjugated to sulphate and excreted into urine.
The production and excretion of 6-Sulfatoxy- melatonin follows an individual’s circadian rhythm, like Melatonin. Measurement of 6-Sulfatoxy- melatonin may be used as an index of pineal function.
For both, clinical and research purpose, the timing of nocturnal onset of 6-Sulfatoxymelatonin has been proposed as a reliable and robust marker of the circadian phase in order to diagnose disorders with an underlying circadian component e.g. advanced or delayed sleep phase syndrome, winter depression, shift work adaptation etc. Moreover, the position of the circadian phase is imperative for the implementation of therapies whose efficacy varies with the phase of the underlying endogenous circadian pacemaker such as the administration of bright light and/or exogenous Melatonin.
Time to results
|5 µl urine|
|EK-M6S 96 wells|
BÜHLMANN has set a focus on automation of its ELISA tests, starting with Calprotectin. A number of validated protocols are available on the commonly use more
Interviews from Dr. Christoph Noppen (Viollier, Allschwil) about the EGFR test from EntroGen and from Dr. Günter Dollenmaier (ZLMSG) about the Anyplex II RV16 test from Seegene
Please read the two new success stories with our new products. You will find the interview with Dr. Christoph Noppen about the evaluation of the EGFR Rea more
TV programme on calprotectin diagnosis for IBD and BÜHLMANN Laboratories on the NHS National Health Channel in the UK. The interviews are scheduled to be more
CALcheck Blue™ is a rapid qualitative screening test. Easy to use, with Quick Prep extraction, no pipetting, no vortexing , reaction time of 10 minutes to more